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Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness

Content Provider	Springer Nature Link
Author	Arenas, M. C. Mateos García, A. Manzanedo, C. Rodríguez Arias, M. Aguilar, M. A. Navarrete, F. Gutiérrez, M. S. García Manzanares, J. Miñarro, J.
Copyright Year	2016
Abstract	Topiramate is an anticonvulsant drug which has been evaluated as a therapeutic option for the treatment of cocaine addiction during the last decade.The purpose of this study was to evaluate the effects of topiramate on the reinforcing actions of cocaine. To this aim, the topiramate-mediated regulation of acquisition and extinction phases of the cocaine conditioned place preference (CPP) was assessed in young-adult mice using three experimental designs.Topiramate (50 mg/kg, p.o.) was given as follows: (1) during cocaine (1 and 25 mg/kg, i.p.) conditioning sessions (4 days) and cocaine (25 mg/kg) post-conditioning session; (2) 2 weeks before and during cocaine conditioning (25 mg/kg); and (3) during extinction of CPP induced by cocaine (25 mg/kg). In the first experimental design, changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene expressions were measured in the ventral tegmental area (VTA).Topiramate significantly increased cocaine-induced CPP and delayed or failed to produce extinction after the first cocaine reinstatement extinction in the first and second experiments. Furthermore, treatment with topiramate after place conditioning blocked the extinction of cocaine-induced CPP. TH and DAT gene expression in the VTA was significantly lower both with topiramate alone and in combination with cocaine compared with animals receiving only cocaine.These findings suggest that topiramate increases the rewarding properties of cocaine, at least in part, by regulating dopaminergic signaling in the mesolimbic circuit. Consequently, the results of this study do not support the use of topiramate for the treatment of problems related to cocaine dependence.• Topiramate increases the rewarding properties of cocaine in CPP• Topiramate alters dopaminergic signaling in the mesolimbic circuit• Topiramate delays the extinction of cocaine-induced CPP• TH and DAT gene expression in the VTA decreases with topiramate and/or with cocaine• Results show that it should limit the use of topiramate in cocaine-dependent subjects
Starting Page	3849
Ending Page	3859
Page Count	11
File Format	PDF
ISSN	00333158
Journal	Psychopharmacology
Volume Number	233
Issue Number	23-24
e-ISSN	14322072
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-09-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Topiramate Cocaine CPP Reward effects Ventral tegmental area Mice Neurosciences Pharmacology/Toxicology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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