NDLI: Haloperidol 2 mg impairs inhibition but not visuospatial attention

Please wait, while we are loading the content...

RETRACTED ARTICLE: A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice

Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion

Safety and tolerability of cariprazine in the long-term treatment of schizophrenia: results from a 48-week, single-arm, open-label extension study

MK-801-induced impairments on the trial-unique, delayed nonmatching-to-location task in rats: effects of acute sodium nitroprusside

Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents

Haloperidol 2 mg impairs inhibition but not visuospatial attention

Naturalistic assessment of demand for cigarettes, snus, and nicotine gum

Differential roles for cortical versus sub-cortical noradrenaline and modulation of impulsivity in the rat

BDNF concentrations and daily fluctuations differ among ADHD children and respond differently to methylphenidate with no relationship with depressive symptomatology

Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice

Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

Pharmacogenetics of stimulant abuse liability: association of CDH13 variant with amphetamine response in a racially-heterogeneous sample of healthy young adults

Nicotinic cholinergic system alterations and nitrous oxide exposure in a mouse model: a hypothesis for the pathobiology of autism spectrum disorder

The BTBR mouse model, cholinergic transmission, and environmental exposure to nitrous oxide

Psychopharmacology : Volume 234, Issue 1, January 2017

Psychopharmacology : Volume 233

Psychopharmacology : Volume 232

Psychopharmacology : Volume 190

Psychopharmacology : Volume 168

Psychopharmacology : Volume 153

Haloperidol 2 mg impairs inhibition but not visuospatial attention

Content Provider	Springer Nature Link
Author	Logemann, H.N. Alexander Böcker, Koen B.E. Deschamps, Peter K.H. Harten, Peter N. Koning, Jeroen Kemner, Chantal Logemann Molnár, Zsófia Kenemans, J. Leon
Copyright Year	2016
Abstract	The dopaminergic system has been implicated in visuospatial attention and inhibition, but the exact role has yet to be elucidated. Scarce literature suggests that attenuation of dopaminergic neurotransmission negatively affects attentional focusing and inhibition. To the best of our knowledge, this is the first study that evaluated the effect of dopaminergic antagonism on stopping performance. Dopaminergic neurotransmission was attenuated in 28 healthy male participants by using 2 mg haloperidol. A repeated-measures placebo-controlled crossover design was implemented, and performance indices of attention and inhibition were assessed in the visual spatial cueing task (VSC) and stop signal task (SST). Additionally, the effect of haloperidol on motoric parameters was assessed. It was expected that haloperidol as contrasted to placebo would result in a reduction of the “validity effect,” the benefit of valid cueing as opposed to invalid cueing of a target in terms of reaction time. Furthermore, an increase in stop signal reaction time (SSRT) in the SST was expected. Results partially confirmed the hypothesis. Haloperidol negatively affected inhibitory motor control in the SST as indexed by SSRT, but there were no indications that haloperidol affected bias or disengagement in the VSC task as indicated by a lack of an effect on RTs. Pertaining to secondary parameters, motor activity increased significantly under haloperidol. Haloperidol negatively affected reaction time variability and errors in both tasks, as well as omissions in the SST, indicating a decreased sustained attention, an increase in premature responses, and an increase in lapses of attention, respectively.
Starting Page	235
Ending Page	244
Page Count	10
File Format	PDF
ISSN	00333158
Journal	Psychopharmacology
Volume Number	234
Issue Number	2
e-ISSN	14322072
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-10-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dopaminergic Dopamine Haloperidol Inhibition Attention Motor activity Neurosciences Pharmacology/Toxicology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dopamine-dependent visual attention preference to social stimuli in nonhuman primates

Levodopa impairs probabilistic reversal learning in healthy young adults

3,4-Methylenedioxymethamphetamine Induces Gene Expression Changes in Rats Related to Serotonergic and Dopaminergic Systems, But Not to Neurotoxicity

Genes of the dopaminergic system selectively modulate top-down but not bottom-up attention

Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP$^{+}$), a metabolite of haloperidol, to synthetic melanin: Implications for the dopaminergic neurotoxicity of HPP$^{+}$

Dopamine D$_{2}$ agonist priming in intact and dopamine-lesioned rats

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice

Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease

Effects of nicotine on response inhibition and interference control

Haloperidol 2 mg impairs inhibition but not visuospatial attention

Similar Documents

Dopamine-dependent visual attention preference to social stimuli in nonhuman primates

Levodopa impairs probabilistic reversal learning in healthy young adults

3,4-Methylenedioxymethamphetamine Induces Gene Expression Changes in Rats Related to Serotonergic and Dopaminergic Systems, But Not to Neurotoxicity

Genes of the dopaminergic system selectively modulate top-down but not bottom-up attention

Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP$^{+}$), a metabolite of haloperidol, to synthetic melanin: Implications for the dopaminergic neurotoxicity of HPP$^{+}$

Dopamine D$_{2}$ agonist priming in intact and dopamine-lesioned rats

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice

Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease

Effects of nicotine on response inhibition and interference control

Haloperidol 2 mg impairs inhibition but not visuospatial attention