NDLI: Cytoprotective Effects of Curcumin on Sodium Fluoride-Induced Intoxication in Rat Erythrocytes

Content Provider	Springer Nature Link
Author	Nabavi, Seyed Fazel Nabavi, Seyed Mohammad Abolhasani, Fatemeh Moghaddam, Akbar Hajizadeh Eslami, Shahram
Copyright Year	2011
Abstract	Curcumin is well known for its potent antioxidant activity. The result of numerous studies showed that antioxidants can protect against fluoride-induced toxicity. In the present study, protective effects of curcumin against sodium fluoride-induced toxicity in rat erythrocytes were evaluated. Curcumin (10 and 20 mg/kg) and vitamin C (10 mg/kg) were administrated intraperitoneally for 1 week followed by sodium fluoride (600 ppm) treatment for next week. Erythrocytes were isolated and superoxide dismutase and catalase activities as well as the levels of reduced glutathione, and lipid peroxidation were measured. The level of malondialdehyde in sodium fluoride treated rats (595.13 ± 20.23 nmol/g Hb) increased compared to the normal rats (315.44 ± 9.76 nmol/g Hb). Animals which were pretreated with curcumin at 20 mg/kg for 1 week prior to sodium fluoride intoxication showed significant reduction in the malondialdehyde level (320.22 ± 9.28 nmol/g Hb). Also, pretreated with curcumin (20 mg/kg) and vitamin C restored the superoxide dismutase and catalase activities and modified the level of reduced glutathione compared with control group (p > 0.01).
Starting Page	486
Ending Page	490
Page Count	5
File Format	PDF
ISSN	00074861
Journal	Bulletin of Environmental Contamination and Toxicology
Volume Number	88
Issue Number	3
e-ISSN	14320800
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-12-06
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Curcumin Erythrocyte Oxidative stress Sodium fluoride Environmental Chemistry Environmental Health Ecotoxicology Pollution Soil Science & Conservation Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Pollution Medicine Toxicology

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