NDLI: Validation of Rapid Assimilation of PCBs Following IP Dosing in the Round Goby (Neogobius melanostomus)

Content Provider	Springer Nature Link
Author	O’Neil, Jessica A. Johnson, Timothy B. Drouillard, Ken G.
Copyright Year	2013
Abstract	The assimilation of polychlorinated biphenyls (PCBs) in round gobies (Neogobius melanostomus) after intraperitoneal (IP) injection was compared to PCBs bioaccumulated by the same fish through natural exposure (“native” PCBs). Lipid equivalent corrected dorsal muscle: whole body concentration ratios for native PCB 153 averaged 1.16 ± 0.77 and ranged from 1.19 to 1.24 for three IP dosed non-native PCBs within 6 h after dosing. Variation in tissue distribution of IP-dosed congeners was reduced after benchmarking to PCB 153, reinforcing that assimilation of the IP dose occurred into muscle rapidly after injection. Despite the use of small oil volumes during injection (<10 μL per fish), coefficients of variation of IP-dosed PCBs were equivalent to those observed for native PCBs. The results suggest that IP dosing provides a precise method to achieve target concentrations of hydrophobic chemicals in small fish and does not require several days to achieve assimilation into highly perfused tissues.
Starting Page	135
Ending Page	140
Page Count	6
File Format	PDF
ISSN	00074861
Journal	Bulletin of Environmental Contamination and Toxicology
Volume Number	91
Issue Number	2
e-ISSN	14320800
Language	English
Publisher	Springer US
Publisher Date	2013-06-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Polychlorinated biphenyls Toxicokinetics Tissue distribution Bioaccumulation Dosing method POPs Pollution Environmental Health Ecotoxicology Soil Science & Conservation Environmental Chemistry Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Pollution Medicine Toxicology

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