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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ibrahim, Ahmed M. A. Kim, Yonggyun |
| Copyright Year | 2007 |
| Abstract | Several immunosuppressive factors are associated with parasitism of an endoparasitoid wasp, Cotesia plutellae, on the diamondback moth, Plutella xylostella. C. plutellae bracovirus (CpBV) encodes a large number of putative protein tyrosine phosphatases (PTPs), which may play a role in inhibiting host cellular immunity. To address this inhibitory hypothesis of CpBV-PTPs, we performed transient expression of individual CpBV-PTPs in hemocytes of the beet armyworm, Spodoptera exigua, and analyzed their cellular immune responses. Two different forms of CpBV-PTPs were chosen and cloned into a eukaryotic expression vector under the control of the p10 promoter of baculovirus: one with the normal cysteine active site (CpBV-PTP1) and the other with a mutated active site (CpBV-PTP5). The hemocytes transfected with CpBV-PTP1 significantly increased in PTP activity compared to control hemocytes, but those with CpBV-PTP5 exhibited a significant decrease in the PTP activity. All transfected hemocytes exhibited a significant reduction in both cell spreading and encapsulation activities compared to control hemocytes. Co-transfection of CpBV-PTP1 together with its double-stranded RNA reduced the messenger RNA (mRNA) level of CpBV-PTP1 and resulted in recovery of both hemocyte behaviors. This is the first report demonstrating that the polydnaviral PTPs can manipulate PTP activity of the hemocytes to interrupt cellular immune responses. |
| Starting Page | 25 |
| Ending Page | 32 |
| Page Count | 8 |
| File Format | |
| ISSN | 00281042 |
| Journal | Naturwissenschaften |
| Volume Number | 95 |
| Issue Number | 1 |
| e-ISSN | 14321904 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2007-07-24 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cotesia plutellae Polydnavirus Protein tyrosine phosphatase RNA interference CpBV Environment Life Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Ecology, Evolution, Behavior and Systematics |
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