NDLI: The biology and clinical implications of prostate cancer dormancy and metastasis

Content Provider	Springer Nature Link
Author	Morrissey, Colm Vessella, Robert L. Lange, Paul H. Lam, Hung Ming
Copyright Year	2015
Abstract	Disseminated tumor cells (DTCs) are detected early in the disease process in prostate cancer (PCa) patients and can persist after radical prostatectomy. DTCs can remain dormant in patients with no evidence of disease for a prolonged period of time only to recur 10 or more years later. Recent advances in single-cell genomics and transcriptomics have provided much needed insight into DTC biology and cancer dormancy in patients. With the development of new in vitro and preclinical models, researchers recapitulate the clinical events in patients and therefore allow further elucidation of the molecular mechanisms underlying cancer dormancy and escape. In this review, we explore novel ideas on the detection, heterogeneous transcriptomic profiles, molecular and cellular mechanisms of dormancy, and potential mechanisms underlying dormancy escape by DTCs. As such, there is hope that identifying and targeting novel dormancy-associated pathways in patients with residual disease will have significant clinical implications for the treatment of PCa patients in the future.
Starting Page	259
Ending Page	265
Page Count	7
File Format	PDF
ISSN	09462716
Journal	Journal of Molecular Medicine
Volume Number	94
Issue Number	3
e-ISSN	14321440
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-10-21
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Disseminated tumor cells Dormancy Microenvironment Bone marrow Prostate cancer Metastasis Molecular Medicine Human Genetics Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Genetics (clinical)

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