NDLI: Hepatitis C virus: evasion of the interferon-induced antiviral response

Content Provider	Springer Nature Link
Author	Taylor, Deborah R.
Copyright Year	2000
Abstract	Hepatitis C virus (HCV) is an emerging virus of great medical significance. A low drug-response rate and a high frequency of persistent infection have caused HCV to reach pandemic proportions. Many infected individuals go on to develop liver cirrhosis and hepatocellular carcinoma, and HCV is now the leading reason for liver transplants in the United States. Differences in genotype response to interferon therapy suggests that one or more viral genes may participate in evasion of the interferon-mediated cellular antiviral response. This review focuses on the viral genes that interact with the host cell to evade the interferon response and on the insights that these interactions may provide into HCV pathogenesis.
Starting Page	182
Ending Page	190
Page Count	9
File Format	PDF
ISSN	09462716
Journal	Journal of Molecular Medicine
Volume Number	78
Issue Number	4
e-ISSN	14321440
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-04-28
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Molecular Medicine Human Genetics Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Genetics (clinical)

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Hepatitis C virus: evasion of the interferon-induced antiviral response