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| Content Provider | Springer Nature Link |
|---|---|
| Author | Artunc, Ferruh Amann, Kerstin Nasir, Omaima Friedrich, Björn Sandulache, Diana Jahovic, Nermina Risler, Teut Vallon, Volker Wulff, Peer Kuhl, Dietmar Lang, Florian |
| Copyright Year | 2006 |
| Abstract | Mineralocorticoids stimulate renal tubular Na+ reabsorption, enhance salt appetite, increase blood pressure, and favor the development of renal fibrosis. The effects of mineralocorticoids on renal tubular Na+ reabsorption and salt appetite involve the serum- and glucocorticoid-inducible kinase 1 (SGK1). The kinase is highly expressed in fibrosing tissue. The present experiments thus explored the involvement of SGK1 in renal fibrosis. To this end, SGK1-knockout mice (sgk1 −/−) and their wild-type littermates (sgk1 +/+) were implanted with desoxycorticosterone acetate (DOCA)-release pellets and offered 1% saline as drinking water for 12 weeks. The treatment led to significant increases in fluid and Na+ intake and urinary output of fluid and Na+ in sgk1 +/+ mice, effects blunted in sgk1 −/− mice. Blood pressure increased within the first 7 weeks to a similar extent in both genotypes, but within the next 5 weeks, it increased further only in sgk1 +/+ mice. Creatinine clearance did not change significantly but albuminuria increased dramatically in sgk1 +/+ mice, an effect significantly blunted in sgk1 −/− mice. Histology after 12 weeks treatment revealed marked glomerular sclerosis and tubulointerstitial damage with interstitial fibrosis and inflammation in kidneys from sgk1 +/+ mice, but not from sgk1 −/− mice. In conclusion, a lack of SGK1 protects against DOCA/high-salt-induced albuminuria and renal fibrosis. |
| Starting Page | 737 |
| Ending Page | 746 |
| Page Count | 10 |
| File Format | |
| ISSN | 09462716 |
| Journal | Journal of Molecular Medicine |
| Volume Number | 84 |
| Issue Number | 9 |
| e-ISSN | 14321440 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2006-08-10 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Sodium Signal transduction Collagen Hormones Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Molecular Medicine Genetics (clinical) |
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