NDLI: PLZF and the (pro)renin receptor

Content Provider	Springer Nature Link
Author	Schefe, Jan H. Unger, Thomas Funke Kaiser, Heiko
Copyright Year	2008
Abstract	For many years, angiotensin II with its respective receptors was considered to be the only effector molecule within the renin–angiotensin system. Nevertheless, several studies indicated that renin (the enzyme catalyzing the generation of angiotensin I) and its enzymatically inactive precursor prorenin may have an angiotensin-II-independent (patho)physiological significance. In 2002, a specific (pro)renin receptor ((P)RR)) which increases the enzymatic activity of its ligands and induces an intrinsic activity upon ligand binding has been published. Recently, our group has demonstrated a novel (P)RR signal transduction pathway involving direct protein–protein interaction between the (P)RR and the transcription factor promyelocytic zinc finger protein (PLZF) and the nuclear translocation of PLZF upon renin stimulation. Downstream effects of (P)RR activation by renin included repression of the (P)RR itself and induction of the p85α subunit of the phosphatidylinositol-3 kinase (PI3K-p85α) as well as an increase in proliferation and a decrease in apoptotic activity. Various animal models demonstrated that inhibition of prorenin binding to the (P)RR can prevent or even abolish the development of cardiac fibrosis and diabetic nephropathy via angiotensin-II-independent mechanisms. Additional studies that verify these remarkable findings are needed. Moreover, the potency of aliskiren (the first orally active renin inhibitor in the market) to interfere with a putatively detrimental binding of (pro)renin to the (P)RR is of particular interest and has to be elucidated.
Starting Page	623
Ending Page	627
Page Count	5
File Format	PDF
ISSN	09462716
Journal	Journal of Molecular Medicine
Volume Number	86
Issue Number	6
e-ISSN	14321440
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-03-12
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Renin Prorenin (Pro) Renin receptor PLZF Internal Medicine Human Genetics Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Genetics (clinical)

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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