NDLI: Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer’s disease

Content Provider	Springer Nature Link
Author	Yang, Zhongduo Zhang, Dongbo Ren, Jin Yang, Mingjun Li, Shuo
Copyright Year	2011
Abstract	Alzheimer’s disease (AD) is a progressive degenerative neurologic disorder resulting in impaired memory and behavior. A promising treatment strategy for AD has been the use of acetylcholinesterase (AChE) inhibitors. Several potent AChE inhibitors such as huperzine and galanthamine were originally isolated from plants, indicating that herbal medicines are a good source for the search of potential AChE inhibitors. In our study, to search for potential AChE inhibitors, the total alkaloidal extracts of 31 Chinese herbal medicines were tested for their AChE inhibitory activities by Ellman’s method and modified TLC bioautographic assay. The results showed that the alkaloidal extracts of Uncaria rhynchophylla (Rubiaceae), Nelumbo nucifera (Nymphaeaceae), Zanthoxylum nitidum (Rutaceae), Portulaca oleracea (Portulacaceae), and Pinellia ternata (Araceae) exhibited remarkable AChE inhibitory activities at the final concentration of 100 μg/ml. Their IC50 values were 10.8, 12.2, 17.4, 29.4, and 56.2 μg/ml, respectively. The rest of the alkaloidal extracts showed no or very weak AChE inhibitory activities at the same concentration. The results of this study indicate that the screening of traditional Chinese herbs for AChE inhibitory activity may provide useful lead compounds in the discovery of new drugs for the treatment of AD.
Starting Page	734
Ending Page	738
Page Count	5
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	21
Issue Number	6
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-02-05
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease Acetylcholinesterase Alkaloid Ellman’s method TLC bioautography Traditional Chinese herbal medicine Cell Biology Biochemistry Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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