NDLI: 3-Indol carboxaldehyde, an imidazole synthesized from naphthoquinone β-lapachone downregulates Candida albicans biofilm

Content Provider	Springer Nature Link
Author	Curvelo, José Alexandre da Rocha Barreto, Anna Lea Silva Anjos, Camila A. Santana, Rafaela S. Alonso, Ariadne Nunes Romas, Maria Teresa Vilela Moura, Kelly C. G. Carneiro, Paula Fernandes Portela, Maristela Barbosa Pinto, Maria do Carmo F. R. Soares, Rosangela Maria de Araújo
Copyright Year	2014
Abstract	Candida species can cause infections that range from superficial to life-threatening events. Candida albicans is an opportunistic pathogen of human microbiota, and it is frequently described as a commensal organism, but in many cases, it can assume a pathogenic behavior. The increasing number of immunocompromised patients has promoted an increase in the incidence of microorganisms that are resistant to conventional therapy. Additionally, the limited number of antifungal drugs has made the search for new compounds extremely relevant. In this study, we determined the minimal inhibitory concentrations (MICs) of two synthetic imidazoles derived from β-lapachone, namely 3-indol carboxaldehyde and p-N(CH3)2-benzaldehyde against a clinical isolate of C. albicans resistant to fluconazole and the reference strain ATCC 10231. Both strains had their growth affected by 3-indol carboxaldehyde, and the MICs were calculated as 31.7 and 41 μg ml−1 for ATCC 10231 and the clinical isolate, respectively. However, the p-N(CH3)2-benzaldehyde MIC values were above 100 μg ml−1 for both strains. Morphogenesis assays revealed that 3-indol carboxaldehyde inhibited significantly the germ tube transformation process. Moreover, this azole was also able to interfere significantly with biofilm formation of both strains, and also demonstrated the ability to disaggregate mature biofilms. The results obtained in this study indicate that 3-indol carboxaldehyde may be considered a viable alternative in modulating C. albicans biofilm and viability.
Starting Page	1155
Ending Page	1161
Page Count	7
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	24
Issue Number	3
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2014-08-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Candida Albicans Imidazole Morpho-differentiation Biofilm Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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