NDLI: Effect of metabolites isolated from Cuscuta pedicellata on high fat diet-fed rats

Content Provider	Springer Nature Link
Author	Zekry, Salwa H. Abo elmatty, Dina M. Zayed, Rawia A. Radwan, Mohamed M. ElSohly, Mahmoud A. Hassanean, Hashim A. Ahmed, Safwat A.
Copyright Year	2014
Abstract	The aim of the present study was to determine if Cuscuta pedicellata extract has an effect on body weight and serum lipid profile in the HFD-fed rats’ animal model. The ethanol extract of C. pedicellata exhibited a significant reduction in body weight and serum lipid profile in this model. The n-hexane/EtOAc (1:1), EtOAc and MeOH/EtOAc (1:1) fractions were also active, while the MeOH fraction showed no beneficial effect. Bioactivity-guided fractionation leads to the isolation of ten pure compounds: naringenin (1), kaempferol (2), aromadenderin (3), quercitin (4), 3,5,7,3′,5′-pentahydroxy flavanone (5), naringenin -7-O-β-d-glucoside (6), aromadenderin -7-O-β-d-glucoside (7), Taxifolin -7-O-β-d-glucoside (8), kaempferol -3-O-β-d-glucoside (astragalin), (9) and quercitin -3-O-β-d-glucoside (isoquercitrin) (10). This is the first report of compounds 1, 3, 5, 6, 7, and 8 in Cuscuta pedicellata. Compound 1 > compound 8 > compound 3 > compound 7 > compound 4 > compound 2 are responsible for the potency of the ethanol extract, while compound 6 was only effective in reducing the total cholesterol serum levels but not effective in reducing the level of triglycerides or the body weight. Our data confirmed the anti-obesity effect of C. pedicellata reported by the Egyptian population and identified the compounds responsible for this activity.
Starting Page	1964
Ending Page	1973
Page Count	10
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	24
Issue Number	5
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2014-09-27
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cuscuta pedicellata Obesity Flavonoids Orlistat® Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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