NDLI: Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

Content Provider	Springer Nature Link
Author	Dhorajiya, Bhaveshkumar D. Ibrahim, Ahmed S. Badria, Farid A. Dholakiya, Bharatkumar Z.
Copyright Year	2013
Abstract	Cancer today remains one of the most deadly diseases in the world. In search of novel anticancer agents, a series of newly hybrid molecules were designed and synthesized by combining the structural features of nucleobase and barbiturate derivatives using the concept of green chemistry. This approach was accomplished efficiently using the aqueous medium to give the corresponding products in a high yield. The newly synthesized compounds were characterized by spectral analysis FT-IR, 1H NMR, 13C-NMR, HMBC, MASS and elemental analysis. Evaluations of these molecules over four cell lines panel of human cancer cells have identified several compounds with significant anticancer activities against one or more cell lines. Compounds TBC and TBA proved to exhibit a wide cytotoxic effect on the tested four cell lines at (IC50 16–24 μM) and (IC50 25–34 μM), respectively. Other compounds, e.g., 1,3-BA, showed a selective cytotoxicity against HepG2 at 7 μM. Taken together, this study has led to the development of a convenient, a highly yielded, and an environmentally friendly synthetic method of highly promising leads for cancer fighting.
Starting Page	839
Ending Page	847
Page Count	9
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	23
Issue Number	2
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2013-08-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Green chemistry Barbiturates Cytotoxicity Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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