NDLI: Synthesis, antimicrobial, analgesic activity, and molecular docking studies of novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde derivatives

Content Provider	Springer Nature Link
Author	Jayanna, N. D. Vagdevi, H. M. Dharshan, J. C. Raghavendra, R. Telkar, Sandeep B.
Copyright Year	2013
Abstract	Condensation of 5,7-dichloro-2-hydrazino-1,3-benzoxazole 3 with different aromatic acetophenones in methanol using catalytic amount of glacial acetic acid afforded the corresponding 1-phenylethanone(5,7-dichloro-1,3-benzoxazol-2-yl)hydrazones 5a–e in good yield. The compounds 5a–e, when subjected to Vilsmeier–Haack reaction with POCl3 in DMF yielded (5,7-dichloro-1,3-benzoxazol-2-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde derivatives 6a–e. The structural assignments of the compounds 6a–e are based on their spectral data and elemental analysis. The obtained compounds were tested for antimicrobial and analgesic activities, and subjected to molecular docking studies with respect to antimicrobial activity. The compound 6b showed pronounced antimicrobial and analgesic activity and exhibited an interesting binding profile with very high receptor affinity.
Starting Page	5814
Ending Page	5822
Page Count	9
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	22
Issue Number	12
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2013-03-16
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dichlorobenzoxazole Antimicrobial Analgesic activity Vilsmeier–Haack Molecular docking Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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