NDLI: Synthesis and cytotoxic activity of dibutyltin complexes derived from pyridoxamine and salicylaldehydes

Content Provider	Springer Nature Link
Author	Galván Hidalgo, José M. Gómez, Elizabeth Ramírez Apan, Teresa Nieto Camacho, Antonio Hernández Ortega, Simón
Copyright Year	2015
Abstract	The synthesis of monomeric pentacoordinated diorganotin complexes derived from pyridoxamine dihydrochloride and substituted salicylaldehydes is described. The complexes were characterized using UV/Vis, IR, MS, as well as 1H, 13C, and 119Sn NMR techniques; the molecular structure of the 1e complex was established by X-ray diffraction, which showed a distorted trigonal bipyramidal geometry, in which the basal plane is defined by the butyl groups and the azomethine nitrogen atom, whereas the oxygen atoms from the aromatic ring occupy axial positions. The cytotoxic activity of the complexes against human cell lines U-251 (glioblastoma), PC-3 (prostate), K-562 (chronic myelogenous leukemia), HCT-15 (human colorectal), MCF-7 (human breast), SKLU-1 (non-small cell lung), and MDA-MB-251 (human breast) was evaluated, and the inhibitory percentage values indicated higher activities than the reference standard, cis-platin, and non-cytotoxic activity was observed in culture of mononuclear cells from peripheral blood on healthy Wistar rats. Oral toxicity studies were performed by the OECD test guide line 423 and reveals that LD50 of complexes 1a, 1b, 1c–1g is in the range of 200–300 mg/Kg body weight and can be classified under category 3, the complexes 1c and 1h resulted to be the less toxic.
Starting Page	3621
Ending Page	3631
Page Count	11
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	24
Issue Number	10
e-ISSN	15548120
Language	English
Publisher	Springer US
Publisher Date	2015-07-16
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pyridoxamine Schiff base Organotin Cytotoxic activity Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

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