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| Content Provider | Springer Nature Link | 
|---|---|
| Author | Platel, Jean Claude Kelsch, Wolfgang | 
| Copyright Year | 2013 | 
| Abstract | It is now widely accepted that neurogenesis continues throughout life. Accumulating evidence suggests that neurotransmitters are essential signaling molecules that control the different steps of neurogenesis. Nevertheless, we are only beginning to understand the precise role of neurotransmitter receptors and in particular excitatory glutamatergic transmission in the differentiation of adult-born neurons. Recent technical advances allow single-cell gene deletion to study cell-autonomous effects during the maturation of adult-born neurons. Single-cell gene deletion overcomes some of the difficulties in interpreting global gene deletion effects on entire brain areas or systemic pharmacological approaches that might result in compensatory circuit effects. The aim of this review is to summarize recent advances in the understanding of the role of NMDA receptors (NMDARs) during the differentiation of adult-born neurons and put them in perspective with previous findings on cortical development. | 
| Starting Page | 3591 | 
| Ending Page | 3601 | 
| Page Count | 11 | 
| File Format | |
| ISSN | 1420682X | 
| Journal | Cellular and Molecular Life Sciences | 
| Volume Number | 70 | 
| Issue Number | 19 | 
| e-ISSN | 14209071 | 
| Language | English | 
| Publisher | Springer Basel | 
| Publisher Date | 2013-02-09 | 
| Publisher Place | Basel | 
| Access Restriction | Subscribed | 
| Subject Keyword | Adult neurogenesis NMDA Glutamate Cortex development Cell Biology Biomedicine general Life Sciences Biochemistry | 
| Content Type | Text | 
| Resource Type | Article | 
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience | 
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