NDLI: Hepatocyte growth factor in invasive growth of carcinomas

Content Provider	Springer Nature Link
Author	Desiderio, M. A.
Copyright Year	2007
Abstract	Hepatocyte growth factor is a multifunctional cytokine of the tumor microenvironment. An important advance in the knowledge of cancer progression has been the appreciation that the tumor invasive phenotype is strongly influenced by microenvironmental stimuli. Malignant tumor cells recruit vasculature and stroma through the production of growth factors and cytokines. The locally activated microenvironment (both cellular and extracellular elements) in turn modifies the proliferative and invasive behavior of the tumor cells. Hepatocyte growth factor accomplishes most of the functions of the invasive program in carcinomas (loss of adhesive junctions, motility, angiogenesis, survival/apoptosis), and may interact with other signals such as hypoxia. The purpose of the present review is to highlight examples of the progress in this area. The influence of hepatocyte growth factors on the carcinoma invasive phenotype is considered by evaluating the gene targets and the network of transcription factors activated in the specific responses.
Starting Page	1341
Ending Page	1354
Page Count	14
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	64
Issue Number	11
e-ISSN	14209071
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2007-04-06
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Hepatocyte growth factors Met receptor carcinoma invasiveness tumor microenvironment transcription factors chemokine receptor HIF-1α E-cadherins/β-catenin Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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