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| Content Provider | Springer Nature Link |
|---|---|
| Author | Dahlbäck, B. Nielsen, L. B. |
| Copyright Year | 2009 |
| Abstract | Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin ß-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 μM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-ß HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties. |
| Starting Page | 559 |
| Ending Page | 564 |
| Page Count | 6 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 66 |
| Issue Number | 4 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | Birkhäuser-Verlag |
| Publisher Date | 2009-01-21 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | HDL LDL VLDL cholesterol apolipoprotein apoA-1 apoM lipocalin signal peptide megalin HNF-1α LRH-1 Foxa2 Cell Biology Biomedicine general Life Sciences Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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