NDLI: Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao

Content Provider	Springer Nature Link
Author	Chen, J. Deng, M. He, Q. Meng, E. Jiang, L. Liao, Z. Rong, M. Liang, S.
Copyright Year	2008
Abstract	Cystine knot toxins (CKTs) in spider venoms represent a rich source of novel ligands for varied ion channels. Here, we identified 95 novel putative CKT precursors by analyzing expressed sequence tags of the tarantula Chilobrachys jingzhao venom gland. Phylogenetics analyses revealed one orphan family and six families with sequence similarity to known toxins. To further investigate the relationships of their structures, functions and evolution, we assayed 10 representative toxins for their effect on ion channels, and performed structure model comparisons, evolution analysis and toxin distribution analysis. This study revealed two major types of CKTs: pore-blocking toxins and gating modifier toxins. A few blockers were observed with relatively high abundance and wide distribution, which may be a category of original toxins that block channels conserved in various preys with relatively high specificity. The gating modifier families contain advanced toxins, usually have many members and interact with diverse regulatory components of channels.
Starting Page	2431
Ending Page	2444
Page Count	14
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	65
Issue Number	15
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2008-06-26
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Toxin molecular diversity classification pore-blocking gating modifier evolution Biochemistry Life Sciences Biomedicine general Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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