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| Content Provider | Springer Nature Link |
|---|---|
| Author | Valdés, R. Fernández Veledo, S. Aymerich, I. Casado, F. J. Pastor Anglada, M. |
| Copyright Year | 2006 |
| Abstract | The nucleoside transporter CNT2 is the highest-affinity adenosine transporter identified so far. Recent evidence suggests that CNT2 has functions other than salvage (i.e. modulation of purinergic responses). Here we identified TGF-β1 as a potent inducer of CNT2 protein expression in liver parenchymal cells. By contrast, CNT1, which is a target of multifunctional cytokines involved in liver cell proliferation, does not respond to TGF-β1 treatment. Cloning of a murine CNT2 gene sequence with promoter-like activity enabled us to demonstrate that this cytokine exerts this effect by transcriptionally activating the CNT2-encoding gene in a JNK-dependent manner. The evidence that CNT2 is not a target of multifunctional cytokines involved in hepatocyte proliferation, but instead, of a cytokine that plays major roles in differentiation and apoptosis, further supports the view that the main physiological role of this transporter protein is not nucleoside salvage. |
| Starting Page | 2527 |
| Ending Page | 2537 |
| Page Count | 11 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 63 |
| Issue Number | 21 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | Birkhäuser-Verlag |
| Publisher Date | 2006-09-29 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | TGF-β nucleoside transporters liver apoptosis CNT2 adenosine Biomedicine general Life Sciences Biochemistry Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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