NDLI: Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life

Content Provider	Springer Nature Link
Author	Peng, Zhenling Yan, Jing Fan, Xiao Mizianty, Marcin J. Xue, Bin Wang, Kui Hu, Gang Uversky, Vladimir N. Kurgan, Lukasz
Copyright Year	2014
Abstract	Recent years witnessed increased interest in intrinsically disordered proteins and regions. These proteins and regions are abundant and possess unique structural features and a broad functional repertoire that complements ordered proteins. However, modern studies on the abundance and functions of intrinsically disordered proteins and regions are relatively limited in size and scope of their analysis. To fill this gap, we performed a broad and detailed computational analysis of over 6 million proteins from 59 archaea, 471 bacterial, 110 eukaryotic and 325 viral proteomes. We used arguably more accurate consensus-based disorder predictions, and for the first time comprehensively characterized intrinsic disorder at proteomic and protein levels from all significant perspectives, including abundance, cellular localization, functional roles, evolution, and impact on structural coverage. We show that intrinsic disorder is more abundant and has a unique profile in eukaryotes. We map disorder into archaea, bacterial and eukaryotic cells, and demonstrate that it is preferentially located in some cellular compartments. Functional analysis that considers over 1,200 annotations shows that certain functions are exclusively implemented by intrinsically disordered proteins and regions, and that some of them are specific to certain domains of life. We reveal that disordered regions are often targets for various post-translational modifications, but primarily in the eukaryotes and viruses. Using a phylogenetic tree for 14 eukaryotic and 112 bacterial species, we analyzed relations between disorder, sequence conservation and evolutionary speed. We provide a complete analysis that clearly shows that intrinsic disorder is exceptionally and uniquely abundant in each domain of life.
Starting Page	137
Ending Page	151
Page Count	15
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	72
Issue Number	1
e-ISSN	14209071
Language	English
Publisher	Springer Basel
Publisher Date	2014-06-18
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Intrinsic disorder Intrinsically disordered proteins Intrinsically disordered regions Cellular localization Post-translational modifications Evolutionary speed Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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