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  1. Cellular and Molecular Life Sciences
  2. Cellular and Molecular Life Sciences : Volume 61
  3. Cellular and Molecular Life Sciences : Volume 61, Issue 17, August 2004
  4. Resistance to β-lactam antibiotics
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Cellular and Molecular Life Sciences : Volume 73
Cellular and Molecular Life Sciences : Volume 72
Cellular and Molecular Life Sciences : Volume 71
Cellular and Molecular Life Sciences : Volume 70
Cellular and Molecular Life Sciences : Volume 69
Cellular and Molecular Life Sciences : Volume 68
Cellular and Molecular Life Sciences : Volume 67
Cellular and Molecular Life Sciences : Volume 66
Cellular and Molecular Life Sciences : Volume 65
Cellular and Molecular Life Sciences : Volume 64
Cellular and Molecular Life Sciences : Volume 63
Cellular and Molecular Life Sciences : Volume 62
Cellular and Molecular Life Sciences : Volume 61
Cellular and Molecular Life Sciences : Volume 61, Issue 24, December 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 23, December 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 21, November 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 22, November 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 19-20, October 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 18, September 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 16, August 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 17, August 2004
DNA damage repair and transcription : Coordination of epigenetic events
DNA damage repair and transcription : Double-strand breaks: signaling pathways and repair mechanisms
DNA damage repair and transcription : DNA repair in a chromatin environment
DNA damage repair and transcription : Chromatin modifiers in transcription and DNA repair
DNA damage repair and transcription : Chromosomal regulation by MeCP2: structural and enzymatic considerations
DNA damage repair and transcription : Gene silencing in DNA damage repair
DNA damage repair and transcription : Functional links between transcription, DNA repair and apoptosis
Focusing on phosphomonohydrolases: a timely choice
Lanthanide-binding peptides and the enzymes that Might Have Been
Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications
Resistance to β-lactam antibiotics
Angiogenesis and signal transduction in endothelial cells
Role of nitric oxide in the functional response to ischemia-reperfusion of heart mitochondria from hyperthyroid rats
Global gene expression of fission yeast in response to cisplatin
Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function
Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks
Cellular and Molecular Life Sciences : Volume 61, Issue 15, July 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 14, July 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 13, June 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 12, June 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 11, May 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 10, May 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 7-8, April 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 9, April 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 5, March 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 6, March 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 4, February 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 3, February 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 2, January 2004
Cellular and Molecular Life Sciences : Volume 61, Issue 1, January 2004
Cellular and Molecular Life Sciences : Volume 60
Cellular and Molecular Life Sciences : Volume 59
Cellular and Molecular Life Sciences : Volume 58
Cellular and Molecular Life Sciences : Volume 57
Cellular and Molecular Life Sciences : Volume 56
Cellular and Molecular Life Sciences : Volume 55
Cellular and Molecular Life Sciences : Volume 54
Cellular and Molecular Life Sciences : Volume 53

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Resistance to β-lactam antibiotics

Content Provider Springer Nature Link
Author Poole, K.
Copyright Year 2004
Abstract β-lactams have a long history in the treatment of infectious diseases, though their use has been and continues to be confounded by the development of resistance in target organisms. β-lactamases, particularly in Gram-negative pathogens, are a major determinant of this resistance, although alterations in the β-lactam targets, the penicillin-binding proteins (PBPs), are also important, especially in Gram-positive pathogens. Mechanisms for the efflux and/or exclusion of these agents also contribute, though often in conjunction these other two. Approaches for overcoming these resistance mechanisms include the development of novel β-lactamase-stable β-lactams, β-lactamase inhibitors to be employed with existing β-lactams, β-lactam compounds that bind strongly to low-affinity PBPs and agents that potentiate the activity of existing β-lactams against low-affinity PBP-producing organisms.
Starting Page 2200
Ending Page 2223
Page Count 24
File Format PDF
ISSN 1420682X
Journal Cellular and Molecular Life Sciences
Volume Number 61
Issue Number 17
e-ISSN 14209071
Language English
Publisher Birkhäuser-Verlag
Publisher Date 2004-01-01
Publisher Place Basel
Access Restriction Subscribed
Content Type Text
Resource Type Article
Subject Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience
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