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  1. Cellular and Molecular Life Sciences
  2. Cellular and Molecular Life Sciences : Volume 57
  3. Cellular and Molecular Life Sciences : Volume 57, Issue 12, November 2000
  4. Hedgehog signalling in cancer
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Cellular and Molecular Life Sciences : Volume 73
Cellular and Molecular Life Sciences : Volume 72
Cellular and Molecular Life Sciences : Volume 71
Cellular and Molecular Life Sciences : Volume 70
Cellular and Molecular Life Sciences : Volume 69
Cellular and Molecular Life Sciences : Volume 68
Cellular and Molecular Life Sciences : Volume 67
Cellular and Molecular Life Sciences : Volume 66
Cellular and Molecular Life Sciences : Volume 65
Cellular and Molecular Life Sciences : Volume 64
Cellular and Molecular Life Sciences : Volume 63
Cellular and Molecular Life Sciences : Volume 62
Cellular and Molecular Life Sciences : Volume 61
Cellular and Molecular Life Sciences : Volume 60
Cellular and Molecular Life Sciences : Volume 59
Cellular and Molecular Life Sciences : Volume 58
Cellular and Molecular Life Sciences : Volume 57
Cellular and Molecular Life Sciences : Volume 57, Issue 13-14, December 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 12, November 2000
Introduction: Preface to the Hedgehog family of proteins review volume
Sonic hedgehog signaling pathway in vertebrate epithelial appendage morphogenesis: perspectives in development and evolution
Hedgehog signaling in vertebrate and invertebrate limb patterning
The role of Sonic hedgehog in neural tube patterning
The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly
Hedgehog signalling in cancer
D-Amino acid oxidase: new findings
Structural studies on nuclear receptors
Avian influenza viruses infecting humans
Single-cell recordings from chick pineal glands in vitro reveal ultradian and circadian oscillations
Diet influences the colonisation of Campylobacter jejuni and distribution of mucin carbohydrates in the chick intestinal tract
4-Hydroxynonenal-modified amyloid-β peptide inhibits the proteasome: possible importance in Alzheimer’s disease*
Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome
Cellular and Molecular Life Sciences : Volume 57, Issue 11, October 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 10, September 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 8-9, August 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 7, July 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 6, June 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 5, May 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 4, April 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 3, March 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 2, February 2000
Cellular and Molecular Life Sciences : Volume 57, Issue 1, January 2000
Cellular and Molecular Life Sciences : Volume 56
Cellular and Molecular Life Sciences : Volume 55
Cellular and Molecular Life Sciences : Volume 54
Cellular and Molecular Life Sciences : Volume 53

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Hedgehog signalling in cancer

Content Provider Springer Nature Link
Author Toftgård, R.
Copyright Year 2000
Abstract Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer. It now appears that constitutive activation of Hedgehog signalling, by inactivating mutations in PTCH1 or activating mutations in the coreceptor SMOH, is required and possibly sufficient for basal cell carcinoma development and also contributes to the formation of a variety of other tumour types, including medulloblastoma and rhabdomyosarcoma. Several lines of evidence, including transgenic mice experiments, suggest that the critical cellular effect is stimulation of proliferation mediated by the transcriptional effector GLI1. Additional components of the signal transduction machinery as well as essential target genes remain to be identified, and involvement of the Hedgehog signalling pathway in other tumour types and/or hereditary cancer predisposition syndromes is to be expected.
Starting Page 1720
Ending Page 1731
Page Count 12
File Format PDF
ISSN 1420682X
Journal Cellular and Molecular Life Sciences
Volume Number 57
Issue Number 12
e-ISSN 14209071
Language English
Publisher Birkhäuser Verlag
Publisher Date 2000-11-01
Publisher Place Basel
Access Restriction Subscribed
Content Type Text
Resource Type Article
Subject Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience
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