NDLI: Characterization of tumor differentiation factor (TDF) and its receptor (TDF-R)

Content Provider	Springer Nature Link
Author	Sokolowska, Izabela Woods, Alisa G. Gawiwicz, Mary Ann Roy, Urmi Darie, Costel C.
Copyright Year	2012
Abstract	Tumor differentiation factor (TDF) is an under-investigated protein produced by the pituitary with no definitive function. TDF is secreted into the bloodstream and targets the breast and prostate, suggesting that it has an endocrine function. Initially, TDF was indirectly discovered based on the differentiation effect of alkaline pituitary extracts of the mammosomatotropic tumor MtTWlO on MTW9/PI rat mammary tumor cells. Years later, the cDNA clone responsible for this differentiation activity was isolated from a human pituitary cDNA library using expression cloning. The cDNA encoded a 108-amino-acid polypeptide that had differentiation activity on MCF7 breast cancer cells and on DU145 prostate cancer cells in vitro and in vivo. Recently, our group focused on identification of the TDF receptor (TDF-R). As potential TDF-R candidates, we identified the members of the Heat Shock 70-kDa family of proteins (HSP70) in both MCF7 and BT-549 human breast cancer cells (HBCC) and PC3, DU145, and LNCaP human prostate cancer cells (HPCC), but not in HeLa cells, NG108 neuroblastoma, or HDF-a and BLK CL.4 cells fibroblasts or fibroblast-like cells. Here we review the current advances on TDF, with particular focus on the structural investigation of its receptor and on its functional effects on breast and prostate cells.
Starting Page	2835
Ending Page	2848
Page Count	14
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	70
Issue Number	16
e-ISSN	14209071
Language	English
Publisher	Springer Basel
Publisher Date	2012-10-18
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Tumor differentiation factor Receptor Differentiation Mass spectrometry Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Retinoic acid signaling and neuronal differentiation

Mass spectrometry-based proteomics in the life sciences

Identification and characterization of a highly thermostable bacteriophage lysozyme

Dependence receptors: between life and death

Transcriptional control of natural killer cell differentiation and function

Protein profiling of 3T3-L1 adipocyte differentiation and (tumor necrosis factor α-mediated) starvation

Erratum to: Systems biology for molecular life sciences and its impact in biomedicine

Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

Characterization of tumor differentiation factor (TDF) and its receptor (TDF-R)

Similar Documents

Retinoic acid signaling and neuronal differentiation

Mass spectrometry-based proteomics in the life sciences

Identification and characterization of a highly thermostable bacteriophage lysozyme

Dependence receptors: between life and death

Transcriptional control of natural killer cell differentiation and function

Protein profiling of 3T3-L1 adipocyte differentiation and (tumor necrosis factor α-mediated) starvation

Erratum to: Systems biology for molecular life sciences and its impact in biomedicine

Tumor necrosis factor-mediated cell death: to break or to burst, that’s the question

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

Characterization of tumor differentiation factor (TDF) and its receptor (TDF-R)