NDLI: The tumor necrosis factor α of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner

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The tumor necrosis factor α of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner

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The tumor necrosis factor α of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner

Content Provider	Springer Nature Link
Author	García Castillo, J. Chaves Pozo, E. Olivares, P. Pelegín, P. Meseguer, J. Mulero, V.
Copyright Year	2004
Abstract	Information on the bioactivities of non-mammalian cytokines is scant due to the lack of the recombinant molecules and specific antibodies. We produced the mature predicted peptide of tumor necrosis factor α (TNFα) from the bony fish gilthead seabream (Sparus aurata L.) (sbTNFα), and its biological role was determined in vitro and in vivo. We first demonstrated by analytical size-exclusion chromatography that sbTNFα is an oligomeric protein but the dimer appears to predominate over the trimeric form, in contrast to mammalian TNFα. Intraperitoneal injection of native sbTNFα resulted in (i) priming of the respiratory burst of the peritoneal exudate and head-kidney (HK) leukocytes, the latter being the bone marrow equivalent in fish; (ii) rapid recruitment of phagocytic granulocytes to the injection site, and (iii) induction of granulopoiesis in the HK. Interestingly, sbTNFα was able to induce a strong proliferation of HK cells in vitro, whereas human TNFα did not. Conversely, sbTNFα was not cytotoxic for murine L929 fibroblasts.
Starting Page	1331
Ending Page	1340
Page Count	10
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	61
Issue Number	11
e-ISSN	14209071
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2004-01-01
Publisher Place	Basel
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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The tumor necrosis factor α of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner

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