NDLI: Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease

Content Provider	Springer Nature Link
Author	Herrera, Andrea Muñoz, Patricia Paris, Irmgard Díaz Veliz, Gabriela Mora, Sergio Inzunza, Jose Hultenby, Kjell Cardenas, Cesar Jaña, Fabián Raisman Vozari, Rita Gysling, Katia Abarca, Jorge Steinbusch, Harry W. M. Segura Aguilar, Juan
Copyright Year	2016
Abstract	l-Dopa continues to be the gold drug in Parkinson’s disease (PD) treatment from 1967. The failure to translate successful results from preclinical to clinical studies can be explained by the use of preclinical models which do not reflect what happens in the disease since these induce a rapid and extensive degeneration; for example, MPTP induces a severe Parkinsonism in only 3 days in humans contrasting with the slow degeneration and progression of PD. This study presents a new anatomy and develops preclinical model based on aminochrome which induces a slow and progressive dysfunction of dopaminergic neurons. The unilateral injection of aminochrome into rat striatum resulted in (1) contralateral rotation when the animals are stimulated with apomorphine; (2) absence of significant loss of tyrosine hydroxylase-positive neuronal elements both in substantia nigra and striatum; (3) cell shrinkage; (4) significant reduction of dopamine release; (5) significant increase in GABA release; (6) significant decrease in the number of monoaminergic presynaptic vesicles; (7) significant increase of dopamine concentration inside of monoaminergic vesicles; (8) significant increase of damaged mitochondria; (9) significant decrease of ATP level in the striatum (10) significant decrease in basal and maximal mitochondrial respiration. These results suggest that aminochrome induces dysfunction of dopaminergic neurons where the contralateral behavior can be explained by aminochrome-induced ATP decrease required both for anterograde transport of synaptic vesicles and dopamine release. Aminochrome could be implemented as a new model neurotoxin to study Parkinson’s disease.
Starting Page	3583
Ending Page	3597
Page Count	15
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	73
Issue Number	18
e-ISSN	14209071
Language	English
Publisher	Springer International Publishing
Publisher Date	2016-03-21
Publisher Place	Cham
Access Restriction	Subscribed
Subject Keyword	Preclinical model Dopamine, neurodegeneration Drugs Mitochondria Presynaptic vesicles Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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