NDLI: Fluctuation and response in biology

Content Provider	Springer Nature Link
Author	Lehner, Ben Kaneko, Kunihiko
Copyright Year	2010
Abstract	In 1905, Albert Einstein proposed that the forces that cause the random Brownian motion of a particle also underlie the resistance to macroscopic motion when a force is applied. This insight, of a coupling between fluctuation (stochastic behavior) and responsiveness (non-stochastic behavior), founded an important branch of physics. Here we argue that his insight may also be relevant for understanding evolved biological systems, and we present a ‘fluctuation–response relationship’ for biology. The relationship is consistent with the idea that biological systems are similarly canalized to stochastic, environmental, and genetic perturbations. It is also supported by in silico evolution experiments, and by the observation that ‘noisy’ gene expression is often both more responsive and more ‘evolvable’. More generally, we argue that in biology there is (and always has been) an important role for macroscopic theory that considers the general behavior of systems without concern for their intimate molecular details.
Starting Page	1005
Ending Page	1010
Page Count	6
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	68
Issue Number	6
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2010-11-30
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Noise Plasticity Canalization Evolvability Fluctuation Response Genetic assimilation Gene expression Cell Biology Biochemistry Life Sciences Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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