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| Content Provider | Springer Nature Link |
|---|---|
| Author | Dubois, Vanessa Laurent, Michaël Boonen, Steven Vanderschueren, Dirk Claessens, Frank |
| Copyright Year | 2011 |
| Abstract | Androgens increase both the size and strength of skeletal muscle via diverse mechanisms. The aim of this review is to discuss the different cellular targets of androgens in skeletal muscle as well as the respective androgen actions in these cells leading to changes in proliferation, myogenic differentiation, and protein metabolism. Androgens bind and activate a specific nuclear receptor which will directly affect the transcription of target genes. These genes encode muscle-specific transcription factors, enzymes, structural proteins, as well as microRNAs. In addition, anabolic action of androgens is partly established through crosstalk with other signaling molecules such as Akt, myostatin, IGF-I, and Notch. Finally, androgens may also exert non-genomic effects in muscle by increasing Ca2+ uptake and modulating kinase activities. In conclusion, the anabolic effect of androgens on skeletal muscle is not only explained by activation of the myocyte androgen receptor but is also the combined result of many genomic and non-genomic actions. |
| Starting Page | 1651 |
| Ending Page | 1667 |
| Page Count | 17 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 69 |
| Issue Number | 10 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2011-11-19 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | Androgens Androgen receptor Skeletal muscle Satellite cells Myostatin IGF-I Non-genomic signaling Biomedicine general Cell Biology Life Sciences Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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