NDLI: Today’s and tomorrow’s imaging and circulating biomarkers for pulmonary arterial hypertension

Content Provider	Springer Nature Link
Author	Barrier, Marjorie Meloche, Jolyane Jacob, Maria Helena Courboulin, Audrey Provencher, Steeve Bonnet, Sébastien
Copyright Year	2012
Abstract	The pathobiology of pulmonary arterial hypertension (PAH) involves a remodeling process in distal pulmonary arteries, as well as vasoconstriction and in situ thrombosis, leading to an increase in pulmonary vascular resistance, right heart failure and death. Its etiology may be idiopathic, but PAH is also frequently associated with underlying conditions such as connective tissue diseases. During the past decade, more than welcome novel therapies have been developed and are in development, including those increasingly targeting the remodeling process. These therapeutic options modestly increase the patients’ long-term survival, now approaching 60% at 5 years. However, non-invasive tools for confirming PAH diagnosis, and assessing disease severity and response to therapy, are tragically lacking and would help to select the best treatment. After exclusion of other causes of pulmonary hypertension, a final diagnosis still relies on right heart catheterization, an invasive technique which cannot be repeated as often as an optimal follow-up might require. Similarly, other techniques and biomarkers used for assessing disease severity and response to treatment generally lack specificity and have significant limitations. In this review, imaging as well as current and future circulating biomarkers for diagnosis, prognosis, and follow-up are discussed.
Starting Page	2805
Ending Page	2831
Page Count	27
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	69
Issue Number	17
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2012-03-25
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Pulmonary arterial hypertension Biomarkers Imaging Circulating biomarkers Biochemistry Cell Biology Life Sciences Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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