NDLI: Cell adhesion molecule control of planar spindle orientation

Content Provider	Springer Nature Link
Author	Tuncay, Hüseyin Ebnet, Klaus
Copyright Year	2015
Abstract	Polarized epithelial cells align the mitotic spindle in the plane of the sheet to maintain tissue integrity and to prevent malignant transformation. The orientation of the spindle apparatus is regulated by the immobilization of the astral microtubules at the lateral cortex and depends on the precise localization of the dynein–dynactin motor protein complex which captures microtubule plus ends and generates pulling forces towards the centrosomes. Recent developments indicate that signals derived from intercellular junctions are required for the stable interaction of the dynein–dynactin complex with the cortex. Here, we review the molecular mechanisms that regulate planar spindle orientation in polarized epithelial cells and we illustrate how different cell adhesion molecules through distinct and non-overlapping mechanisms instruct the cells to align the mitotic spindle in the plane of the sheet.
Starting Page	1195
Ending Page	1207
Page Count	13
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	73
Issue Number	6
e-ISSN	14209071
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-12-23
Publisher Place	Cham
Access Restriction	Subscribed
Subject Keyword	Cadherin Cdc42 Cortical actin JAM-A Junctional adhesion molecules LGN MDCK PtdIns(3,4,5)P3 Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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