NDLI: Signaling pathway in nerve growth factor induced histamine release from rat mast cells

Content Provider	Springer Nature Link
Author	Štempelj, M. Ferjan, I.
Copyright Year	2005
Abstract	Objective and Design: We investigated a signal transduction pathway involved in NGF induced histamine secretion from mast cells. We compared this mechanism with the exocytosis induced by basic secretagogue compound 48/80.Materials and Methods: Isolated rat peritoneal mast cells were obtained from male Wistar rats. Histamine release was assayed spectrofl uorometrically.Results: We found that tyrosine kinase inhibitor genistein, phospholipase C (PLC) inhibitor U-73122, phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor wortmannin, protein kinase C (PKC) inhibitors, staurosporine and GF109203X, but not MAP kinase inhibitors, SB203580 and PD98059, reduce histamine secretion in NGF provoked mast cell degranulation. In compound 48/80 mediated degranulation, we confi rmed only the involvement of tyrosine kinase and PLC, but not PI-3 kinase, PKC and MAP kinases.Conclusions: Our results indicate that release of histamine from mast cells after stimulation with NGF is regulated by tyrosine kinase, PLC, PI-3 kinase and PKC, but not by MAP kinases. This biochemical pathway differs from that provoked by compound 48/80.
Starting Page	344
Ending Page	349
Page Count	6
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	54
Issue Number	8
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2005-01-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mast cells NGF Compound 48/80 Histamine release Signal transduction Pharmacology/Toxicology Dermatology Neurology Rheumatology Immunology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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