NDLI: Involvement of histamine and histamine H2 receptors in nicotinamide-induced differentiation of human amniotic epithelial cells into insulin-producing cells

Content Provider	Springer Nature Link
Author	Szukiewicz, D. Szewczyk, G. Mittal, T. K. Rongies, W. Maslinski, S.
Copyright Year	2009
Abstract	Human amniotic epithelial cells (HAEC) resemble stem cells in their ability to differentiate into all three germ layers: endoderm, mesoderm, and ectoderm. Histamine receptors are expressed on HAEC. We examined the influence of histamine, and H1 and H2 antagonists on the generation of pancreatic islet beta-like cells from HAEC.HAEC were isolated after term pregnancies (N = 12) and cultured for 14 days with nicotinamide (10 mM) in normoxia. Altogether, 72 cultures were established. Histamine (100 μM) effects were investigated with mepyramine (10 μM) or cimetidine (10 μM). After 7 and 14 days, the mean concentration of C-peptide (MCCP) in the culture medium was measured immunoenzymatically as a marker of pancreatic differentiation.MCCP was approximately threefold higher on day 14, compared to day 7. Histamine significantly increased MCCP, and more evident differences were observed after 7 days of culture than after 14 days. The mean percent increase ±SEM in MCCP amounted to 142.19 ± 21.7 and 79.03 ± 12.35 compared to the controls on day 7 and 14, respectively. H2 blockade significantly reduced histamine-related increase in MCCP, both on day 7 and 14 by 88.7 ± 14.3 and 39.2 ± 12.4%, respectively. H1 receptor antagonist did not affect MCPP.Nicotinamide-induced pancreatic differentiation of HAEC into beta-like cells may be augmented, probably at its earlier stage, by histamine acting via H2 receptors.
Starting Page	209
Ending Page	211
Page Count	3
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	59
Issue Number	2
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2009-12-11
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Histamine Histamine H2 receptor Amniotic epithelial cells Pancreatic differentiation Neurology Dermatology Allergology Rheumatology Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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