NDLI: Age-related changes in sympathetic modulation of sensory nerve activity in rat skin

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Inflammation Research : Volume 47, Issue 5, May 1998

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Inflammation Research : Volume 46

Age-related changes in sympathetic modulation of sensory nerve activity in rat skin

Content Provider	Springer Nature Link
Author	Merhi, M. Helme, R. D. Khalil, Z.
Copyright Year	1998
Abstract	Objectives: Sensory nerves play an important role in mediating neurogenic inflammation and subsequent tissue healing. A decrease in sensory nerve function with increasing age has been reported to correlate with poor tissue healing. Sympathetic nerves are known to modulate sensory nerve function, and changes in this modulation could also have important implications with ageing. The aims of this study were to examine the effect of different frequency electrical stimulation (ES) on the microvascular responses obtained to sensory nerve activation in young, aged and capsaicin-pretreated rats and modulation of these responses by sympathetic efferents.¶Methods: Using laser Doppler flowmetry, vascular responses to antidromic ES of the sciatic nerve were monitored in the base of vacuum-induced blisters in the hind footpad. The non-selective α-adrenoceptor antagonist phentolamine (3 mg/kg, i.v.) was administered 20 min prior to ES.¶Results: At high frequency ES (20 V, 2 ms, 15 Hz for 1 min), the vascular response in old rats was significantly reduced (46% decrease, p < 0.05) compared to young control. At low frequency ES (20 V, 2 ms, 5 Hz for 1 min) however, older rats produced similar vascular responses to the young. Capsaicin-pretreated rats showed significantly reduced vascular responses to both high and low frequency ES, regardless of age. Pretreatment with phentolamine significantly increased the microvascular response in young rats at high (87%) and low (36%) frequency ES. In contrast, phentolamine significantly increased the ES-induced response in old rats at high frequency only (147% increase).¶Conclusions: The results suggest that the aged sensory nerve responds preferentially to low frequency ES and that sympathetic efferents exert an inhibitory modulatory effect on the vascular response evoked by sensory nerve stimulation. There are age-related changes in sympathetic modulation of sensory nerve-mediated responses which is dependent on stimulation frequency.
Starting Page	239
Ending Page	244
Page Count	6
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	47
Issue Number	6
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2014-02-12
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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