NDLI: Histamine, xanthine oxidase generated oxygen-derived free radicals and Helicobacter pylori in gastroduodenal inflammation and ulceration

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Histamine, xanthine oxidase generated oxygen-derived free radicals and Helicobacter pylori in gastroduodenal inflammation and ulceration

Inflammation Research : Volume 47, Issue 3, March 1998

Inflammation Research : Volume 47, Issue 1, Supplement,March 1998

Inflammation Research : Volume 47, Issue 2, February 1998

Inflammation Research : Volume 47, Issue 1, January 1998

Inflammation Research : Volume 46

Histamine, xanthine oxidase generated oxygen-derived free radicals and Helicobacter pylori in gastroduodenal inflammation and ulceration

Content Provider	Springer Nature Link
Author	Ben Hamida, A. Man, W. K. McNeil, N. Spencer, J.
Copyright Year	1998
Abstract	Objective: The relationship between Helicobacter pylori (H. pylori), xanthine oxidase (XO)-induced oxygen derived free radicals (ODFR) and histamine in the induction of human gastroduodenal disorders was investigated.¶Patients and Methods: Histamine concentration, XO and xanthine dehydrogenase (XD) activities were measured in endoscopically obtained biopsies from 66 symptomatic patients.¶Results: H. pylori infection was associated with lower oxyntic and duodenal histamine in ‘normal’ controls (group N) (p < 0.002 and p < 0.05, respectively). Patients with gastroduodenal disease tended to have reduced mucosal concentration of histamine, but comparing H. pylori positive and negative patients, infection did not lead to a further fall in histamine concentration. H. pylori positive duodenal ulcer (DU) patients tended to have higher XO activity than group N (p = 0.051) and had a significantly lowered activity of XD, the precursor of XO (p′ < 0.05). Histamine concentration at the ulcer-edge was lower while XO activity was higher than in the distant normal mucosa (p < 0.05, respectively). Gastritis (group GL) with H. pylori also had lower XD than H. pylori positive group N (p′ < 0.025) but no corresponding rise in XO activity. In group N, duodenal mucosal histamine and XD activity were inversely related (Rs = −0.51, p < 0.025).¶Conclusions: These findings support the hypothesis that histamine, xanthine oxidase related ODFR, and H. pylori may be closely associated in the manifestations of chronic duodenal ulcer.
Starting Page	193
Ending Page	199
Page Count	7
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	47
Issue Number	4
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2014-02-08
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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