NDLI: Enhancement of activated β1-integrin expression by prostaglandin E2 via EP receptors in isolated human coronary arterial endothelial cells: implication for the treatment of Kawasaki disease

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Enhancement of activated β1-integrin expression by prostaglandin E2 via EP receptors in isolated human coronary arterial endothelial cells: implication for the treatment of Kawasaki disease

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Enhancement of activated β1-integrin expression by prostaglandin E2 via EP receptors in isolated human coronary arterial endothelial cells: implication for the treatment of Kawasaki disease

Content Provider	Springer Nature Link
Author	Kajimoto, M. Ichiyama, T. Ue, Y. Shiraishi, M. Hasegawa, M. Furukawa, S.
Copyright Year	2009
Abstract	Plasma prostaglandin E2 (PGE2) levels are markedly elevated in acute Kawasaki disease (KD). We evaluated the function of the EP receptors in the expression of activated β1-integrin stimulated by PGE2 in human coronary arterial endothelial cells (HCAEC).We determined the mRNA expression of the PGE2 receptors, EP receptors (EP1-4) in HCAEC by RT-PCR and protein expression by Western blotting. We evaluated the function of the EP receptors in the expression of activated β1-integrin stimulated by PGE2 in HCAEC, using antagonists and agonists of the EP receptors, by flow cytometry.RT-PCR revealed mRNAs for all four EP receptors in HCAEC. Western blotting demonstrated EP1, EP2 and EP3 expression in HCAEC. The EP2 and EP3 agonists enhanced the expression of activated β1-integrin in HCAEC. The potency of the EP2 agonist was significantly greater than that of the EP3 agonist. Pretreatment with the EP1, EP2 and EP3 antagonists inhibited the expression of activated β1-integrin induced by PGE2 in HCAEC. The potency of the EP2 antagonist was significantly greater than that of the EP1 and EP3 antagonists.Our results suggest that PGE2 mainly induces the activation of β1-integrins via the EP2 receptor in HCAEC. Our results further suggest that the EP2 antagonist modulates the inflammatory response during KD vasculitis.
Starting Page	224
Ending Page	228
Page Count	5
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	58
Issue Number	4
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2009-01-24
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	β1-integrin Coronary artery endothelial cells Prostaglandin E2 Prostaglandin E receptor Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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