NDLI: Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis

Content Provider	Springer Nature Link
Author	Ma, Z. H. Ma, Q. Y. Wang, L. C. Sha, H. C. Wu, S. L. Zhang, M.
Copyright Year	2005
Abstract	Objective: The literature on resveratrol in severe acute pancreatitis (SAP) is limited though it has been widely studied in infections and trauma. The aim of this study was to investigate the inhibitory effect of resveratrol on inflammatory responses in a rat model of SAP.Methods: Male Sprague-Dawley (SD) rats were randomly divided into 3 groups: SAP group, resveratrol group and control group. 4.0% sodium taurocholate was injected into the pancreatic duct to induce SAP. In the resveratrol group, resveratrol (10 mg/kg) was injected through penal vein 5 min after SAP was induced. The peritoneal macrophages of the rats were collected 3, 6 and 12 h after stimulus and then incubated for 24 h. The expression of nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) in peritoneal macrophages was measured. The levels of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and nitric oxide (NO) in culture medium of peritoneal macrophages and serum of rats were evaluated.Results: Histological examination of pancreas indicated that the damage in the SAP group was more severe than that in the resveratrol group. The expression of NF-κB and iNOS in peritoneal macrophages was significantly higher in the SAP group than in the resveratrol group. The concentrations of TNF-α, IL-1 and NO in culture medium and serum were significantly elevated in the SAP group when compared with the resveratrol group.Conclusions: The inhibiting effect on the inflammatory response and the decreased expression of TNF-α, IL-1 and NO in peritoneal macrophages suggest resveratrol as a novel anti-inflammatory agent for reducing the severity of SAP.
Starting Page	522
Ending Page	527
Page Count	6
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	54
Issue Number	12
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2005-01-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pancreatitis Macrophages Resveratrol Pharmacology/Toxicology Dermatology Neurology Rheumatology Immunology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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