NDLI: The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice

Content Provider	Springer Nature Link
Author	Martín, A. R. Villegas, I. Alarcón de la Lastra, C.
Copyright Year	2005
Abstract	Objective: We have evaluated the efficacy of the selective cyclo-oxygenase (COX)-2 inhibitor, rofecoxib, for the prevention of experimental colitis.Material and methods: To induce colitis BALB/c mice received 5% dextran sulphate sodium (DSS) in their drinking water continuously for 7 days. Rofecoxib (2.5–10 mg/kg body weight, p.o.) was administered throughout the treatment period with DSS. Colitis was quantified by a clinical damage score, colon length, weight loss, stool consistency and rectal bleeding. Inflammatory response was assessed by neutrophil infiltration, determined by histology and myeloperoxidase (MPO) activity. Interleukin (IL)-1β, prostaglandin (PG)E2 and PGD2 levels in colon mucosa and the immunohistochemical expression of COX-1 and −2 were also studied.Results: The COX-2 inhibitor ameliorated severe colitis, reduced the degree of inflammation through reduction of neutrophil infiltration and IL-1β levels. PGE2, and PGD2 synthesis were significantly reduced in DSS-treated groups. Indeed, treatment with rofecoxib diminished the lost of COX-1 caused by DSS in the crypt epithelium whereas expression of COX-2 remained unaffected.Conclusions: Rofecoxib is protective in acute DSS – induced colitis, probably by reducing neutrophil infiltration, inhibiting up-regulation of IL-1β and returning to normal COX-1 expression in the inflamed colonic mucosa.
Starting Page	145
Ending Page	151
Page Count	7
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	54
Issue Number	4
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2005-01-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rofecoxib DSS (dextran sulphate sodium) Neutrophils Interleukin (IL)-1β Prostaglandin (PG) Cyclo-oxygenase (COX) Immunology Pharmacology/Toxicology Allergology Dermatology Neurology Rheumatology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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