NDLI: Sodium caseinate induces mouse granulopoiesis

Content Provider	Springer Nature Link
Author	Domínguez Melendez, V. Silvestre Santana, O. More Fierros, L. Aguiñiga Sánchez, I. Martínez, Ledesma Marroquin Segura, R. García Hernández, A. L. Weiss Steider, B. Marché Cova, A. Monroy García, A. Mora García, L. Santiago Osorio, Edelmiro
Copyright Year	2012
Abstract	Sodium caseinate (CasNa) induces differentiation and M-CSF production in mouse band granulocytes in vitro; however, it is not yet known if this molecule can also induce the proliferation and activation of the granulocyte lineage in vivo. In this work we evaluated the induction in vivo of granulopoiesis and the activation of granulocytes in mice treated with CasNa.BALB/c male mice 8–12 weeks old were used.The animals were inoculated intraperitoneally with 1 ml of CasNa (10% in PBS p/v) four times (every 48 h).Granulocyte proliferation was evaluated by flow cytometry; activation was evaluated by phagocytic indices. The cytokine was measured using an ELISA assay.We show that CasNa increased bone marrow granulopoiesis percentage (38.35 ± 10.88 vs. 64.94 ± 34.14 BrdU+/Gr-1+ cells) and the granulocytes generated presented increased phagocytic indices (0.3 ± 0.1 vs. 0.6 ± 0.11, p < 0.05). We also show that G-CSF (974 ± 411 vs. 3189 ± 350 pg/ml, p < 0.05) and GM-CSF increased in serum, but only G-CSF in bone marrow plasma.CasNa induces granulopoiesis with functional granulocytes, suggesting that this molecule could be an innate immune system activator.
Starting Page	367
Ending Page	373
Page Count	7
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	61
Issue Number	4
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2012-01-20
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cytokine Granulocytes Phagocytosis Sodium caseinate Allergology Immunology Pharmacology/Toxicology Rheumatology Neurology Dermatology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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