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| Content Provider | Springer Nature Link |
|---|---|
| Author | Takeuchi, Takato Sekiyama, Kazunari Sekigawa, Akio Fujita, Masayo Waragai, Masaaki Sugama, Shuei Iwamaru, Yoshifumi Kitani, Hiroshi Hashimoto, Makoto |
| Copyright Year | 2010 |
| Abstract | A recent study suggested that neuroinflammation plays a major role in the pathogenesis of a number of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Although the precise mechanism is obscure, dysregulation of the signaling transduction pathway in microglia may enhance inflammation, leading to synaptic dysfunction and ultimately to neuronal cell death. The expression and function of the P2X7 receptor (P2X7R), an ATP-gated ion channel abundantly expressed in microglia in the brain, is significantly up-regulated in the postmortem brain of Alzheimer’s disease patients and various neurodegenerative disease animal models. This supports the role of the P2X7R pathway in the progression of neurodegeneration. Blocking P2X7R using brilliant blue G, a P2X7R antagonist that can cross the blood–brain barrier, has been shown to result in the amelioration of neuropathology in various animal models. Taken together, these results raise the possibility that the P2X7R signaling pathway could be a therapeutic target for treating various neurodegenerative diseases. |
| Starting Page | 91 |
| Ending Page | 96 |
| Page Count | 6 |
| File Format | |
| ISSN | 0004069X |
| Journal | Archivum Immunologiae et Therapiae Experimentalis |
| Volume Number | 58 |
| Issue Number | 2 |
| e-ISSN | 16614917 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2010-02-09 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | P2X7 receptor Microglia Neuroinflammation Neurodegenerative disease Pharmacology/Toxicology Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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