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  1. Archivum Immunologiae et Therapiae Experimentalis
  2. Archivum Immunologiae et Therapiae Experimentalis : Volume 57
  3. Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 6, December 2009
  4. Cardiomyocyte death in doxorubicin-induced cardiotoxicity
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Archivum Immunologiae et Therapiae Experimentalis : Volume 65
Archivum Immunologiae et Therapiae Experimentalis : Volume 64
Archivum Immunologiae et Therapiae Experimentalis : Volume 63
Archivum Immunologiae et Therapiae Experimentalis : Volume 62
Archivum Immunologiae et Therapiae Experimentalis : Volume 61
Archivum Immunologiae et Therapiae Experimentalis : Volume 60
Archivum Immunologiae et Therapiae Experimentalis : Volume 59
Archivum Immunologiae et Therapiae Experimentalis : Volume 58
Archivum Immunologiae et Therapiae Experimentalis : Volume 57
Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 6, December 2009
Complement: coming full circle
Recent advances in multivalent self adjuvanting glycolipopeptide vaccine strategies against breast cancer
Exploring the immune response against Mycobacterium tuberculosis for a better diagnosis of the infection
Cardiomyocyte death in doxorubicin-induced cardiotoxicity
CD40-activated B cells from patients with systemic lupus erythematosus can be modulated by therapeutic immunoglobulins in vitro
Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation
Cellular glucose transport and glucotransporter 4 expression as a therapeutic target: clinical and experimental studies
Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 5, October 2009
Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 4, August 2009
Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 3, June 2009
Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 2, April 2009
Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 1, February 2009
Archivum Immunologiae et Therapiae Experimentalis : Volume 56
Archivum Immunologiae et Therapiae Experimentalis : Volume 55
Archivum Immunologiae et Therapiae Experimentalis : Volume 54

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Cardiomyocyte death in doxorubicin-induced cardiotoxicity

Content Provider Springer Nature Link
Author Zhang, Yi Wei Shi, Jianjian Li, Yuan Jian Wei, Lei
Copyright Year 2009
Abstract Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in cancer therapeutic practice for decades. With the increasing population of cancer survivors, there is a growing need to develop preventive strategies and effective therapies against DOX-induced cardiotoxicity, in particular late-onset cardiomyopathy. Although intensive investigations on DOX-induced cardiotoxicity have continued for decades, the underlying mechanisms responsible for DOX-induced cardiotoxicity have not been completely elucidated. A rapidly expanding body of evidence supports the notion that cardiomyocyte death by apoptosis and necrosis is a primary mechanism of DOX-induced cardiomyopathy and that other types of cell death, such as autophagy and senescence/aging, may participate in this process. This review focuses on the current understanding of the molecular mechanisms underlying DOX-induced cardiomyocyte death, including the major primary mechanism of excess production of reactive oxygen species (ROS) and other recently discovered ROS-independent mechanisms. The different sensitivities to DOX-induced cell death signals between adult and young cardiomyocytes will also be discussed.
Starting Page 435
Ending Page 445
Page Count 11
File Format PDF
ISSN 0004069X
Journal Archivum Immunologiae et Therapiae Experimentalis
Volume Number 57
Issue Number 6
e-ISSN 16614917
Language English
Publisher SP Birkhäuser Verlag Basel
Publisher Date 2009-10-29
Publisher Place Basel
Access Restriction Subscribed
Subject Keyword cardiomyocyte doxorubicin apoptosis necrosis autophagy Pharmacology/Toxicology Immunology
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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