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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhang, Yi Wei Shi, Jianjian Li, Yuan Jian Wei, Lei |
| Copyright Year | 2009 |
| Abstract | Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in cancer therapeutic practice for decades. With the increasing population of cancer survivors, there is a growing need to develop preventive strategies and effective therapies against DOX-induced cardiotoxicity, in particular late-onset cardiomyopathy. Although intensive investigations on DOX-induced cardiotoxicity have continued for decades, the underlying mechanisms responsible for DOX-induced cardiotoxicity have not been completely elucidated. A rapidly expanding body of evidence supports the notion that cardiomyocyte death by apoptosis and necrosis is a primary mechanism of DOX-induced cardiomyopathy and that other types of cell death, such as autophagy and senescence/aging, may participate in this process. This review focuses on the current understanding of the molecular mechanisms underlying DOX-induced cardiomyocyte death, including the major primary mechanism of excess production of reactive oxygen species (ROS) and other recently discovered ROS-independent mechanisms. The different sensitivities to DOX-induced cell death signals between adult and young cardiomyocytes will also be discussed. |
| Starting Page | 435 |
| Ending Page | 445 |
| Page Count | 11 |
| File Format | |
| ISSN | 0004069X |
| Journal | Archivum Immunologiae et Therapiae Experimentalis |
| Volume Number | 57 |
| Issue Number | 6 |
| e-ISSN | 16614917 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2009-10-29 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | cardiomyocyte doxorubicin apoptosis necrosis autophagy Pharmacology/Toxicology Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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