NDLI: Opiate abuse, innate immunity, and bacterial infectious diseases

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Immunochemical studies of the lipopolysaccharides of Hafnia alvei PCM 1219 and other strains with the O-antigens containing D-glucose 1-phosphate and 2-deoxy-2-[(R)-3-hydroxybutyramido]-D-glucose

Archivum Immunologiae et Therapiae Experimentalis : Volume 56, Issue 4, August 2008

Archivum Immunologiae et Therapiae Experimentalis : Volume 56, Issue 3, June 2008

Archivum Immunologiae et Therapiae Experimentalis : Volume 56, Issue 2, April 2008

Archivum Immunologiae et Therapiae Experimentalis : Volume 56, Issue 1, February 2008

Archivum Immunologiae et Therapiae Experimentalis : Volume 55

Archivum Immunologiae et Therapiae Experimentalis : Volume 54

Opiate abuse, innate immunity, and bacterial infectious diseases

Content Provider	Springer Nature Link
Author	Wang, Jinghua Barke, Roderick A. Ma, Jing Charboneau, Richard Roy, Sabita
Copyright Year	2008
Abstract	The first line of defense against invading bacteria is provided by the innate immune system. Morphine and other opiates can immediately disrupt the body’s first line of defense against harmful external bacteria. Opiate, for example morphine, abuse degrades physical and physiologic barriers, and modulates phagocytic cells (macrophages, neutrophils) and, nonspecific cytotoxic T cells (γδ T), natural killer cells, and dendritic cells, that are functionally important for carrying out a rapid immune reaction to invading pathogens. In vitro studies with innate immune cells from experimental animals and humans and in vivo studies with animal models have shown that opiate abuse impairs innate immunity and is responsible for increased susceptibility to bacterial infection. However, to better understand the complex interactions between opiates, innate immunity, and bacterial infection and develop novel approaches to treat and even prevent bacterial infection in the opiate-abuse population, there is an urgent need to fill the numerous gaps in our understanding of the cellular and molecular mechanisms by which opiate abuse increases susceptibility to bacterial infection.
Starting Page	299
Ending Page	309
Page Count	11
File Format	PDF
ISSN	0004069X
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	56
Issue Number	5
e-ISSN	16614917
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2008-10-06
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	opiate morphine innate immunity macrophages neutrophils dentritic cells NK cells γδ T lymphocytes cytokines bacterial infection Immunology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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