NDLI: Global Weak Solutions in a PDE-ODE System Modeling Multiscale Cancer Cell Invasion

Content Provider	Society for Industrial and Applied Mathematics (SIAM)
Author	Surulescu, Christina Winkler, Michael Stinner, Christian
Copyright Year	2014
Abstract	We prove the global existence, along with some basic boundedness properties, of weak solutions to a PDE-ODE system modeling the multiscale invasion of tumor cells through the surrounding tissue matrix. The model has been proposed in [G. Meral, C. Stinner, and C. Surulescu, On a Multiscale Model Involving Cell Contractivity and its Effects on Tumor Invasion, preprint, TU Kaiserslautern, Kaiserslautern, Germany, 2013] and accounts on the macroscopic level for the evolution of cell and tissue densities, along with the concentration of a chemoattractant, while on the subcellular level it involves the binding of integrins to soluble and insoluble components of the peritumoral region. The connection between the two scales is realized with the aid of a contractivity function characterizing the ability of the tumor cells to adapt their motility behavior to their subcellular dynamics. The resulting system, consisting of three partial and three ordinary differential equations including a temporal delay, in particular involves chemotactic and haptotactic cross diffusion. In order to overcome technical obstacles stemming from the corresponding highest-order interaction terms, we base our analysis on a certain functional, inter alia involving the cell and tissue densities in the diffusion and haptotaxis terms, respectively, which is shown to enjoy a quasi-dissipative property. This will be used as a starting point for the derivation of a series of integral estimates finally allowing for the construction of a generalized solution as the limit of solutions to suitably regularized problems.
Starting Page	1969
Ending Page	2007
Page Count	39
File Format	PDF
ISSN	00361410
DOI	10.1137/13094058X
e-ISSN	10957154
Journal	SIAM Journal on Mathematical Analysis (SJMAAH)
Issue Number	3
Volume Number	46
Language	English
Publisher	Society for Industrial and Applied Mathematics
Publisher Date	2014-06-10
Access Restriction	Subscribed
Subject Keyword	PDEs in connection with biology and other natural sciences asymptotic behavior delay haptotaxis Cell movement Reaction-diffusion equations multiscale model chemotaxis Asymptotic behavior of solutions
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Analysis Computational Mathematics

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