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Development of epitope-based peptide vaccine against novel Coronavirus 2019 (SARS-COV-2): Immunoinformatics approach
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bhattacharya, Manojit Ranjan Sharma, Ashish Patra, Prasanta Ghosh, Pratik Sharma, Garima Chandra Patra, Bidhan Lee, Sang-Soo Chakraborty, Chiranjib |
| Copyright Year | 2020 |
| Abstract | ABSTRACT Recently, a novel Coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to the SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on Toll-Like Receptor (TLR)-5 to get binding affinity. Therefore, in order to provide a fast immunogenic profile of these epitopes we performed immunoinformatics analysis so that rapid development of vaccine might bring this disastrous situation to the end earlier. This article is protected by copyright. All rights reserved. |
| File Format | HTM / HTML |
| DOI | 10.1002/jmv.25736 |
| Journal | Journal of Medical Virology |
| Language | English |
| Publisher | WHO |
| Access Restriction | Open |
| Rights Holder | unk |
| Content Type | Text |
| Resource Type | Article Preprint |
