Loading...
Please wait, while we are loading the content...
Similar Documents
Multiple mechanisms negatively regulate C. elegans tbx-2 expression
| Content Provider | Semantic Scholar |
|---|---|
| Author | Milton, Angenee C. Okkema, Peter G. |
| Copyright Year | 2011 |
| Abstract | E-box dependent manner and are directly bound by Twist1 in mouse ECC mesenchymal cells. Additional Twist1 candidate genes were identified through Affymetrix microarray analysis of MC3T3-E1 cells treated with control siRNA or Twist1 siRNA. Loss of Twist1 resulted in decreased expression of genes associated with cell proliferation, migration, and ECM components. E-box consensus sites were identified within ECRs of Semaphorin3C, Gadd45a, and Rab39b. All three ECRs are directly bound by Twist1 in mouse ECC mesenchymal cells. These studies identified Twist1 direct transcriptional targets promoting cell proliferation and migration in ECC mesenchymal cells. Therefore, these Twist1 transcriptional target genes likely contribute to maintenance and expansion of valve progenitor cells during early stages of valve development. |
| Starting Page | 261 |
| Ending Page | 261 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.ydbio.2011.05.503 |
| Volume Number | 356 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82233245.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.ydbio.2011.05.503 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
