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Mnemunic Deficits in the Double Y-Maze Are Related to the Effects of Nucleus Basalis Injections of Ibotenic and Quisqualic Acid on Choline Acetylt ~ ansfe ~ as ~ in the Rat Amygdala
| Content Provider | Semantic Scholar |
|---|---|
| Author | Enger, Richard J. |
| Copyright Year | 2002 |
| Abstract | BENINGER, R. J., S. ~~HNEMANN, J .t. INGLES, K. JHAMANDAS AND R. J. BQBGMAN. #@renror,ic de&its in rhe duubie Y-maze are related to the effects of nucleus basalis injections of ibotenic and quisqualic acid on choline acetyltransferase in the rat mnygdala. BRAIN RES BULL 35(2) 147-152, 1994.-Many researchers have reported that the magnitude of decrease In cortical choline acetyhransferase (ChAT) following excitotoxic lesions of the nucleus basalis magnocelluhuis (nbm) is unrelated to the degree of cognitive impairment. Recently, an explanation has been offered for this lack of correlation: different excitotoxins, when injected into the nbm. d~~eren~a~ly affected chotinergic projections to the cortex and amygdala, and those excitotoxins previously reported to produce the greatest mnemonic deficits produced the largest decreases in amygdaloid ChAT. The present study evaluated the role of ~ygda~ofttga~ chohnergic projections in memory by comparing the effects of intra-nbm ibotenic and qulsquahc acid on cortical and amygdaloid ChAT and on mnemonic performance in the double Y-maze. Rats were trained in the double Y-maze until working and reference memory choice accuracy stabilized to a criterion of 2 78% correct. Rats then were given either bilateral quisqualic acid (60 nmol in 0.5 ~1). bilateral ibotenic acid (50 nmol in 0.5 ~1). or sham (0.9% saline in 0.5 ~1) lesions of the nbm, and again were tested on the maze. Quisqualate produced a selective impairment of working memory, a large (51%) decrease in cortical ChAT and *1. small ( 17%) decrease in amygdaloid ChAT; ibotenate, on the other hand, produced a greater jm~ai~ent of’ working memory, an impatient of reference memory, a similar (51%) decrease in cortical ChAT. but a greater (30%) decrease in amygdaloid ChAT. These results suggest that the choiinergic projections from the nbm to the cortex and amygdala play an impartant roIe in memory. They suggest that excitotoxins producing greater depletions of amygdatoid ChAT produce greater mnemonic deficits. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.queensu.ca/psychology/sites/webpublish.queensu.ca.psycwww/files/files/Faculty/Richard%20Beninger/Beninger_prp_71.pdf |
| Alternate Webpage(s) | http://www.queensu.ca/psychology/sites/webpublish.queensu.ca.psycwww/files/files/Faculty/Richard%20Beninger/Beninger_prp_71.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
