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Synthesis of 3-(pyridine-2-yl)-4,5-dihydro-1H-pyrazole-1-thiocarboxamides and their copper(II) complexes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Beloglazkina, Elena Korablina, Diana D. Vorozhtsov, N. I. Sviridova, Ludmila A. Moiseeva, Anna A. Skvortsov, Dmitry A. Rybakov, Victor B. Majouga, Alexander G. Zyk, Nikolai V. |
| Copyright Year | 2017 |
| Abstract | Abstract New organic ligands 3-(pyridine-2-yl)-4,5-dihydro-1H-pyrazole-1-thiocarboxamides (L) have been synthesized by a two or three step reaction sequence starting from substituted benzaldehydes and 2-acetyl pyridine. Copper(II) complexes with LCuCl2 composition were obtained by the reactions of these ligands with CuCl2·2H2O. The crystal structure of two synthesized complexes has been determined by X-ray analysis. Copper atoms located in a strongly distorted square piramidal environment and coordinated by pyrazoline and pyridine nitrogen atoms, thiocarbamoyl sulfur atom and two chloride-anions. All complexes undergo reversible or quasi-reversible electrochemical reduction at 0.45–0.28 V with the formation of Cu(I) containing intermediates. The cytotoxicity of copper containing complexes, comparable to cisplatin and doxorubicin, was demonstrated using cancer cell lines MCF-7, A549 and HEK293. |
| Starting Page | 1050 |
| Ending Page | 1060 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.arabjc.2017.01.005 |
| Volume Number | 12 |
| Alternate Webpage(s) | https://istina.msu.ru/download/59294133/1iDHP4:0HW15Hz-xlw5nGg96B4j1xFxhO8/ |
| Alternate Webpage(s) | https://doi.org/10.1016/j.arabjc.2017.01.005 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
