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Effects of fish-oil supplementation on myocardial fatty acids in humans.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Metcalf, Robert G. James, Michael John Gibson, Robert Edwards, James M. Stubberfield, John Stuklis, Robert G. Roberts-Thomson, Kurt C. Young, Glenn D. Cleland, Leslie G. |
| Copyright Year | 2007 |
| Abstract | BACKGROUND Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids. OBJECTIVE The study examined the kinetics of incorporation of n-3 fatty acids into human myocardial membrane phospholipids during supplementation with fish oil and alpha-linolenic acid-rich flaxseed oil. DESIGN Patients with low self-reported fish intake (<1 fish meal/wk and no oil supplements) accepted for elective cardiac surgery involving cardiopulmonary bypass were randomly allocated to 1 of 6 groups: no supplement; fish oil (6 g EPA+DHA/d) for either 7, 14, or 21 d before surgery; flaxseed oil; or olive oil (both 10 mL/d for 21 d before surgery). Right atrial appendage tissue removed during surgery and blood collected at enrollment and before surgery were analyzed for phospholipid fatty acids. RESULTS Surgery rescheduling resulted in a range of treatment times from 7 to 118 d. In the fish-oil-treated subjects, accumulation of EPA and DHA in the right atrium was curvilinear with time and reached a maximum at approximately 30 d of treatment and displaced mainly arachidonic acid. Flaxseed oil supplementation yielded a small increase in atrial EPA but not DHA, whereas olive oil did not significantly change atrial n-3 fatty acids. CONCLUSION The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation. |
| Starting Page | 53 |
| Ending Page | 60 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://energiaprolongada.com.br/site/artigos/8.pdf |
| PubMed reference number | 17490956v1 |
| Volume Number | 85 |
| Issue Number | 5 |
| Journal | The American journal of clinical nutrition |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arachidonic Acid Arterial Switch Operation Cardiopulmonary Bypass Eicosapentaenoic Acid Fatty Acids, Omega-6 Fatty Liver Fish Oils Heart Atrium Linolenic Acid Linseed Oil Myocardium Myocytes, Cardiac Omega-3 Fatty Acids Phospholipids Right atrial structure Structure of auricular appendage Sudden death Tissue membrane alpha-Linolenic Acid docosahexaenoic acid olive oil |
| Content Type | Text |
| Resource Type | Article |
