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Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mandal, Dindyal Tiwari, Rakesh Kumar Shirazi, Amir Nasrolahi Oh, Donghoon Ye, Guofeng Banerjee, Antara Yadav, Arpita Parang, Keykavous |
| Copyright Year | 2013 |
| Abstract | A number of cyclic peptides including [FR]4, [FK]4, [WR]4, [CR]4, [AK]4, and [WK]n (n = 3-5) containing L-amino acids were produced using solid-phase peptide synthesis. We hypothesized that an optimal balance of hydrophobicity and charge could generate self-assembled nanostructures in aqueous solution by intramolecular and/or intermolecular interactions. Among all the designed peptides, [WR]n (n = 3-5) generated self-assembled vesicle-like nanostructures at room temperature as shown by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and/or dynamic light scattering (DLS). This class of peptides represents the first report of surfactant-like cyclic peptides that self-assemble into nanostructures. A plausible mechanistic insight into the self-assembly of [WR]5 was obtained by molecular modeling studies. Modified [WR]5 analogues, such as [WMeR]5, [WR(Me)2]5, [WMeR(Me)2]5, and [WdR]5, exhibited different morphologies to [WR]5 as shown by TEM observations. [WR]5 exhibited a significant stabilizing effect for generated silver nanoparticles and glyceraldehyde-3-phosphate dehydrogenase activity. These studies established a new class of surfactant-like cyclic peptides that self-assembled into nanostructures and could have potential applications for the stabilization of silver nanoparticles and protein biomolecules. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C3SM50764E |
| PubMed reference number | 24187575 |
| Journal | Medline |
| Volume Number | 9 |
| Issue Number | 39 |
| Alternate Webpage(s) | https://digitalcommons.chapman.edu/cgi/viewcontent.cgi?article=1074&context=pharmacy_articles |
| Alternate Webpage(s) | https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1013&context=bps_facpubs&httpsredir=1&referer= |
| Alternate Webpage(s) | https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1013&context=bps_facpubs |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/sm/c3/c3sm50764e/c3sm50764e.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C3SM50764E |
| Journal | Soft matter |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
