NDLI: Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

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Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Content Provider	Semantic Scholar
Author	Joo, Jinmyoung Kwon, Ester J. Kang, Jinyoung Skalak, Matthew Anglin, Emily J. Mann, Aman P. Ruoslahti, Erkki Bhatia, Sangeeta N. Sailor, Michael J.
Copyright Year	2016
Abstract	We report the synthesis, characterization, and assessment of a nanoparticle-based RNAi delivery platform that protects siRNA payloads against nuclease-induced degradation and efficiently delivers them to target cells. The nanocarrier is based on biodegradable mesoporous silicon nanoparticles (pSiNPs), where the voids of the nanoparticles are loaded with siRNA and the nanoparticles are encapsulated with graphene oxide nanosheets (GO-pSiNPs). The graphene oxide encapsulant delays release of the oligonucleotide payloads in vitro by a factor of 3. When conjugated to a targeting peptide derived from the rabies virus glycoprotein (RVG), the nanoparticles show 2-fold greater cellular uptake and gene silencing. Intravenous administration of the nanoparticles into brain-injured mice results in substantial accumulation specifically at the site of injury.
Starting Page	407
Ending Page	414
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C6NH00082G
Alternate Webpage(s)	http://lmrt.mit.edu/sites/default/files/Joo_NanoHorizons_2016.pdf
Alternate Webpage(s)	http://www.rsc.org/suppdata/c6/nh/c6nh00082g/c6nh00082g1.pdf
PubMed reference number	29732165
Alternate Webpage(s)	https://doi.org/10.1039/C6NH00082G
Journal	Medline
Volume Number	1
Issue Number	5
Journal	Nanoscale horizons
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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