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Electrical properties of acutely isolated, identified rat spinal dorsal horn projection neurons
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Li-Yen Mae |
| Copyright Year | 1987 |
| Abstract | We used a retrograde marker, rhodamine-labeled fluorescent latex microspheres and the enzyme papain to isolate a group of identified, dorsal horn projection neurons from rat spinal cord. This method has allowed us to study the electrical properties of these acutely dissociated cells with patch-clamp techniques. It will also provide us the opportunity to understand the transmitter responses of these neurons that had not undergone culturing manipulation. The isolated projection cells have a short-lasting action potential and fire repetitively under a sustained depolarization. The ionic conductance mechanisms underlying the action potentials were studied under voltage-clamp conditions. Voltage-dependent inward sodium, inward calcium, outward potassium and calcium-activated potassium currents were observed in these cells. |
| Starting Page | 267 |
| Ending Page | 272 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(87)90267-9 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394087902679 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394087902679?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 3696498 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2887%2990267-9 |
| Journal | Medline |
| Volume Number | 82 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
